Corpus ID: 189801070

Effects of 5-Aza-2 '-deoxycytidine and trichostatin A on DNA methylation and expression of hMLH 1 in ovarian cancer cell line COC 1 / DDP

  title={Effects of 5-Aza-2 '-deoxycytidine and trichostatin A on DNA methylation and expression of hMLH 1 in ovarian cancer cell line COC 1 / DDP},
  author={Chun-feng Meng and D. Dai and K. Guo},
Background and Objective: Cisplatin (DDP) can cause DNA damage in cells. DNA mismatchrepair proteins serve to detect DDP-caused DNA damage by generating an injury signal which eventually contributes to the triggering of tumor cell apoptosis. As a member of the mismatch repair system, the absence of hMLH1 expression contributes to the resistance of tumor cells to DDP. This study explores the role of hMLH1 expression and DNA methylation in DDP-resistance of human ovarian cancer, and evaluates the… Expand

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