Effects of 5‐HT drugs in prefrontal cortex during memory formation and the ketamine amnesia‐model

  title={Effects of 5‐HT drugs in prefrontal cortex during memory formation and the ketamine amnesia‐model},
  author={Gustavo Liy-Salmer{\'o}n and Alfredo Meneses},
This article describes a series of experiments investigating the effects of systemic or intraprefrontal administration of serotonergic agents on ketamine induced memory deficits in rats. First, rats were trained on an operant autoshaping task. Immediately after training, rats were injected with different doses of drug or saline. Following drug administration, rats were tested after 1.5 h for short‐term memory (STM) and 24 h for long‐term memory (LTM) of conditioned response. An increase or… 

Effects of the Selective 5-HT7 Receptor Antagonist SB-269970 and Amisulpride on Ketamine-Induced Schizophrenia-like Deficits in Rats

In conclusion, antagonism of 5-HT7 receptors may represent a useful pharmacological approach in the treatment of cognitive deficits and some negative symptoms of schizophrenia.

Investigation of the Role of Stimulation and Blockade of 5-HT7 Receptors in Ketamine Anesthesia.

The influence of a 5-HTR 7 agonist/antagonist on ketamine anesthesia for behavioral impact and its functional impact was assessed by mRNA expression with real-time PCR and immunostaining in the hippocampus and prefrontal cortex of mice.



5-HT1A receptor expression during memory formation

These data suggest that upregulated, downregulated, and “silence” of 5-HT1A receptors in brain areas form part of neural circuits engaged in memory formation by demonstrating a high degree of specificity and memory mapping.

The Physiological Role of 5-HT2A Receptors in Working Memory

It is concluded that prefrontal 5-HT2A receptors have a hitherto unrecognized role in the cognitive function of working memory, which involves actions at both excitatory and inhibitory elements within local circuitry.

Differential increase of extracellular dopamine and serotonin in the ‘prefrontal cortex’ and striatum of pigeons during working memory

It is shown that DA has no unitary function but is differentially released during working as well as short‐term memory in the pigeons' ‘prefrontal’ cortex, showing a triple dissociation between transmitters, structures and tasks within the avian ‘ prefronto’‐striatal system.

Do serotonin1–7 receptors modulate short and long-term memory?

  • A. Meneses
  • Biology, Psychology
    Neurobiology of Learning and Memory
  • 2007

A pharmacological analysis of an associative learning task: 5-HT(1) to 5-HT(7) receptor subtypes function on a pavlovian/instrumental autoshaped memory.

  • A. Meneses
  • Biology, Psychology
    Learning & memory
  • 2003
Results indicate that pharmacological manipulation of 5-HT1-7 receptors or5-HT reuptake sites might modulate memory consolidation, which is consistent with the emerging notion that 5- HT plays a key role in memory formation.

Involvement of 5-HT1A Receptors in Prefrontal Cortex in the Modulation of Dopaminergic Activity: Role in Atypical Antipsychotic Action

The results suggest that the activation of mPFC 5-HT1A receptors enhances the activity of VTA DA neurons and mesocortical DA release, which may be involved in the elevation of extracellular DA produced by atypical antipsychotics.