Effects of 4-nonylphenol on oxidant/antioxidant balance system inducing hepatic steatosis in male rat

@inproceedings{Kourouma2015EffectsO4,
  title={Effects of 4-nonylphenol on oxidant/antioxidant balance system inducing hepatic steatosis in male rat},
  author={A Kouassi S Kourouma and Hady Keita and Peng Duan and Chao Quan and Koikoi Kebe Bilivogui and Suqin Qi and Ndjiembi Adjonga Christiane and Aidogie Osamuyimen and Kedi Yang},
  booktitle={Toxicology reports},
  year={2015}
}
An emerging literature suggests that early life exposure to 4-nonylphenol (4-NP), a widespread endocrine disrupting chemical, may increase the risk of metabolic syndrome. In this study, we investigated the hypothesis that intraperitoneal administration of 4-NP induces hepatic steatosis in rat. 24 male Sprague-Dawley rats were administered with 4-NP (0, 2, 10 and 50 mg/kg b.wt) in corn oil for 30 days. Liver histology, biochemical analysis and gene expression profiling were examined. After… CONTINUE READING