Effects of 4-hydroxytamoxifen and a novel pure antioestrogen (ICI 182780) on the clonogenic growth of human breast cancer cells in vitro.

@article{Defriend1994EffectsO4,
  title={Effects of 4-hydroxytamoxifen and a novel pure antioestrogen (ICI 182780) on the clonogenic growth of human breast cancer cells in vitro.},
  author={David J Defriend and Elizabeth Garratt Anderson and Janine Bell and Deepti P. Wilks and Christopher M. West and Robert E. Mansel and Anthony Howell},
  journal={British Journal of Cancer},
  year={1994},
  volume={70},
  pages={204 - 211}
}
We have investigated the effects on breast cancer cell growth of 4-hydroxytamoxifen (4OHT), a conventional antioestrogen with agonist activity, and 7 alpha-[9-(4,4,5,5,5-pentafluoropentylsulphinyl)nonyl]oestra- 1,3,5,(10)- triene-3,17 beta-diol (ICI 182780), a novel, pure antioestrogen, using established human breast cancer cell lines and cancer cells obtained directly from breast cancer patients with malignant pleural effusions who had relapsed on tamoxifen. The effects of the two agents were… CONTINUE READING

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