Effects of 4-hydroxyantipyrine and its 4-O-sulfate on antipyrine as biodistribution promoter.

@article{Ohkawa2001EffectsO4,
  title={Effects of 4-hydroxyantipyrine and its 4-O-sulfate on antipyrine as biodistribution promoter.},
  author={Y Ohkawa and M Matsumura and Yuji Kurosaki and Masateru Kurumi and Kenji Sasaki and Taiji Nakayama},
  journal={Biological \& pharmaceutical bulletin},
  year={2001},
  volume={24 5},
  pages={
          529-34
        }
}
The effects of 4-hydroxyantipyrine (4-OH), a major metabolite of antipyrine, and its 4-O-sulfate (4-S) on the pharmacokinetics of antipyrine were investigated in rats. Plasma elimination of intravenously administered antipyrine was significantly decelerated under a steady-state concentration of 4-OH but not under that of 4-S. Tissue-to-plasma concentration ratio (Kp) of antipyrine under its steady-state concentration was significantly increased in the brain and heart by the concomitant use of 4… 
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