Effects of 4'-chlorodiazepam on cellular excitation-contraction coupling and ischaemia-reperfusion injury in rabbit heart.

@article{Brown2008EffectsO4,
  title={Effects of 4'-chlorodiazepam on cellular excitation-contraction coupling and ischaemia-reperfusion injury in rabbit heart.},
  author={David Brown and Miguel Antonio Aon and Fadi Gabriel Akar and Ting Liu and Nicolas Sorarrain and Brian O'Rourke},
  journal={Cardiovascular research},
  year={2008},
  volume={79 1},
  pages={141-9}
}
AIMS Recent evidence indicates that the activity of energy-dissipating ion channels in the mitochondria can influence the susceptibility of the heart to ischaemia-reperfusion injury. In this study, we describe the effects of 4'-chlorodiazepam (4-ClDzp), a well-known ligand of the mitochondrial benzodiazepine receptor, on the physiology of both isolated cardiomyocytes and intact hearts. METHODS AND RESULTS We used current- and voltage-clamp methods to determine the effects of 4-ClDzp on… CONTINUE READING

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