Effects of 3 days unloading on molecular regulators of muscle size in humans.

@article{Gustafsson2010EffectsO3,
  title={Effects of 3 days unloading on molecular regulators of muscle size in humans.},
  author={Thomas Gustafsson and Ted Osterlund and John N. Flanagan and Ferdinand Von Walden and Todd A. Trappe and Richard M Linnehan and Per A. Tesch},
  journal={Journal of applied physiology},
  year={2010},
  volume={109 3},
  pages={721-7}
}
Changes in skeletal muscle mass are controlled by mechanisms that dictate protein synthesis or degradation. The current human study explored whether changes in activation of the phosphoinositide 3-kinase (PI3K)-Akt1, p38, myostatin, and mRNA expression of markers of protein degradation and synthesis occur soon after withdrawal of weight bearing. Biopsies of the vastus lateralis muscle (VL) and soleus muscle (Sol) were obtained from eight healthy men before and following 3 days of unilateral… CONTINUE READING