Corpus ID: 24575757

Effects of 3,6-dimethylamino-dibenzopyriodonium edetate on action potentials in guinea pig papillary muscles.

@article{Ji1993EffectsO3,
  title={Effects of 3,6-dimethylamino-dibenzopyriodonium edetate on action potentials in guinea pig papillary muscles.},
  author={G. Ji and D. Zhao and D. Q. Liu and B. Sheng},
  journal={Zhongguo yao li xue bao = Acta pharmacologica Sinica},
  year={1993},
  volume={14 2},
  pages={
          121-4
        }
}
  • G. Ji, D. Zhao, +1 author B. Sheng
  • Published 1993
  • Biology, Medicine
  • Zhongguo yao li xue bao = Acta pharmacologica Sinica
The effects of 3,6-dimethylamino-dibenzopyriodonium edetate (IHC-72) on action potentials (AP) and slow response action potentials of guinea pig papillary muscles were studied with intracellular microelectrodes. IHC-72 12.7, 25.4, and 50.8 mumol.L-1 decreased the maximal upstroke velocity (Vmax), amplitude of action potential (APA), over shot (OS), and resting potential (RP) while prolonged the action potential duration at 30%, 50%, 90%, and 100% repolarization (APD30, APD50, APD90, and APD100… Expand