Effects of 3,4-diaminopyridine on mechanical and electrical responses of frog single muscle fibres.

@article{Khan1983EffectsO3,
  title={Effects of 3,4-diaminopyridine on mechanical and electrical responses of frog single muscle fibres.},
  author={R. Khan and M. Lemeignan},
  journal={Acta pharmacologica et toxicologica},
  year={1983},
  volume={52 3},
  pages={
          181-7
        }
}
The effects of 3,4-diaminopyridine (3,4-DAP) were studied on isolated muscle fibres of the frog in concentrations ranging between 0.025 and 5.0 mM. Isometric twitch and tetanus responses were recorded at temperatures between 2.5 and 3.9 degrees. 3,4-DAP caused a concentration-dependent increase in twitch amplitude, maximum effects being obtained at a concentration of 3 mM with a mean increase in tension of 70 +/- 12% of control (n = 7). 3,4-DAP in 3 mM concentration had only a slight increase… Expand
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