Effects of 3, 5, 3'-triiodothyronine (t3) and follicle stimulating hormone on apoptosis and proliferation of rat ovarian granulosa cells.

@article{Zhang2013EffectsO3,
  title={Effects of 3, 5, 3'-triiodothyronine (t3) and follicle stimulating hormone on apoptosis and proliferation of rat ovarian granulosa cells.},
  author={Cheng Zhang and Li Guo and Baochang Zhu and Yun Feng and Shangyu Yu and Na An and Xiaoxia Wang},
  journal={The Chinese journal of physiology},
  year={2013},
  volume={56 5},
  pages={
          298-305
        }
}
Thyroid hormone (TH) is important for normal reproductive functions and dysregulation of TH support is associated with reproductive disorders. We have previously reported that 3,5,3'-triiodothyronine (T₃) increases follicle stimulating hormone (FSH)-induced preantral follicle growth in vitro. Interaction of hormones with apoptosis and proliferation of granulosa cells is poorly understood. The present study investigated the role and the mechanism of T₃ and/or FSH on granulosa cell apoptosis and… CONTINUE READING

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