Effects of 25-hydroxycholesterol on rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in vivo, in perfused liver, and in hepatocytes.

@article{Erickson1978EffectsO2,
  title={Effects of 25-hydroxycholesterol on rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in vivo, in perfused liver, and in hepatocytes.},
  author={Sandra K. Erickson and Suzanne M. Matsui and M A Shrewsbury and Allen D. Cooper and Robert G. Gould},
  journal={The Journal of biological chemistry},
  year={1978},
  volume={253 12},
  pages={
          4159-64
        }
}
The effects of 25-hydroxycholesterol on 3-hydroxy-3methylglutaryl coenzyme A rednctase activity in rat liver have been investigated in intact rats, in perfused liver, and in isolated hepatocytes. When 25-hydroxycholesterol was fed to rats at a level of 0.1% of the diet for 18 h, reductase activity decreased to about 40% of the control value, but when the regimen was continued for 66 h, the degree of inhibition did not increase, suggesting the possibility that a partial tolerance to the drug had… CONTINUE READING