Effects of 24 CYP2D6 Variants Found in the Chinese Population on the Metabolism of Risperidone.

  title={Effects of 24 CYP2D6 Variants Found in the Chinese Population on the Metabolism of Risperidone.},
  author={Zhen-He Wang and Yun-yun Zhan and Yun-Xuan Li and Cheng-Cheng Yang and Jie Cai and Da-peng Dai and Guoxin Hu and Jianping Cai},
  volume={96 5-6},
AIMS Cytochrome P450 (CYP450) 2D6 is an important member of the P450 enzyme superfamily and responsible for clearing 25% of clinically important drugs. The aim of this study was to assess the catalytic characteristics of 24 CYP2D6 allelic isoforms found in the Chinese population and their effects on the metabolism of risperidone in vitro. METHODS Insect microsomes expressing wild-type CYP2D6 and 24 CYP2D6 allelic variants were incubated with 20-1,000 μmol/l risperidone for 40 min at 37°C… CONTINUE READING

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