Effects of 20 PBDE metabolites on steroidogenesis in the H295R cell line.

  title={Effects of 20 PBDE metabolites on steroidogenesis in the H295R cell line.},
  author={Yuhe He and Margaret Burkhardt Murphy and Richard Man Kit Yu and Michael Hon-Wah Lam and Markus Hecker and John Paul Giesy and Rudolf Shiu Sun Wu and Paul K S Lam},
  journal={Toxicology letters},
  volume={176 3},
Polybrominated diphenyl ethers (PBDEs) are additive flame retardants that have been found in the environment as well as human tissues. Environmental concentrations of these compounds have been increasing in many parts of the world in recent years. Due to their structural similarity, PBDEs are believed to have similar toxicity to PCBs, but their toxicological properties are still being determined. In this study, the steroidogenic effects of hydroxylated, methoxylated and/or chlorinated… CONTINUE READING


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