Effects of 2-methylthio ATP on insulin secretion in the dog in vivo.

@article{Ribes1988EffectsO2,
  title={Effects of 2-methylthio ATP on insulin secretion in the dog in vivo.},
  author={G{\'e}rard Ribes and Gyslaine Bertrand and Pierre Petit and Marie-Madeleine Loubati{\`e}res-Mariani},
  journal={European journal of pharmacology},
  year={1988},
  volume={155 1-2},
  pages={171-4}
}
The effects of 2-methylthio ATP, an ATP analogue that is more specific for the P2Y receptor, were investigated on insulin secretion in the anesthetized dog in vivo. 2-Methylthio ATP was infused directly into the pancreaticoduodenal artery for 15 min. The infusion was performed so as to obtain a pancreaticoduodenal artery blood level of about 15 microM. 2-Methylthio ATP induced an immediate and significant stimulation of insulin secretion measured from the pancreaticoduodenal vein by means of a… CONTINUE READING

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