Effects of 2-methyl-1,4-naphthoquinone (menadione) on myocardial contractility and cardiac sarcoplasmic reticulum Ca-ATPase


(1) In electrically driven guinea-pig left atria, menadione (2-methyl-1,4-naphthoquinone) (1 to 20 μmol/1) and menadione sodium bisulfate (30 to 200 μmol/1) produced marked positive inotropic effects. Endogenously released catecholamines and histamine contributed to 80–85% of the effect, the residual 15–20% appearing as a direct effect. (2) In electrically… (More)
DOI: 10.1007/BF00736060


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