Effects of 2-acetylaminofluorene on liver cell proliferation after partial hepatectomy of female rats.


The effect of the hepatocarcinogen 2-acetylaminofluorene (AAF) on liver regeneration in female Sprague-Dawley rats was studied. While livers of normal female rats were highly resistant to this carcinogen, partial hepatectomy of female animals maintained on diet containing 0.04% AAF disclosed a marked hepatotoxicity which resulted in abnormal, nodular… (More)


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