Effects of 2-Acetylaminofluorene on Liver Cell Proliferation after Partial Hepatectomy of Female Rats1

  • Carlton D. Jackson, Charles C. Irving
  • Published 2006


The effect of the hepatocarcinogen 2-acetylaminofluorene (AAF) on liver regeneration in female Sprague-Dawley rats was studied. While livers of normal female rats were highly resistant to this carcinogen, partial hepatectomy of female animals maintained on diet containing 0.04% AAF disclosed a marked hepatotoxicity which resulted in abnormal, nodular… (More)


3 Figures and Tables