Effects of 2,3-diphosphoglycerate and other organic phosphate compounds on oxygen affinity and intracellular pH of human erythrocytes

@article{Duhm1971EffectsO2,
  title={Effects of 2,3-diphosphoglycerate and other organic phosphate compounds on oxygen affinity and intracellular pH of human erythrocytes},
  author={Jochen Duhm},
  journal={Pfl{\"u}gers Archiv},
  year={1971},
  volume={326},
  pages={341-356}
}
The effects of changes of the 2,3-DPG content and of the total concentration of organic phosphates on the oxygen affinity and the intracellular pH of human erythrocytes were studied. The oxygen affinity as characterized by the P50 (oxygen tension at 50% O2 saturation) increases from 15 to 45 mm Hg when the 2,3-DPG concentration is elevated from 0.1 to 24 μmoles/g by incubation of erythrocytes in the presence of inosine, pyruvate and phosphate. In cells containing normal concentrations of 2,3… CONTINUE READING

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The effect of organic phosphates from the human erythrocyte on the allosteric properties of hemoglobin

  • R. Bcnesch, R. E. Benesch
  • Biochem. biophys. Res. Commun. 26, 162
  • 1967
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