Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on adipogenic differentiation and insulin-induced glucose uptake in 3T3-L1 cells.

@article{Hsu2010EffectsO2,
  title={Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on adipogenic differentiation and insulin-induced glucose uptake in 3T3-L1 cells.},
  author={Hsin-Fen Hsu and Tsui-Chun Tsou and H. W. Chao and Ya-Ting Kuo and F R Tsai and Szu-Ching Yeh},
  journal={Journal of hazardous materials},
  year={2010},
  volume={182 1-3},
  pages={649-55}
}
Dioxin exposure has been positively associated with human type II diabetes. Because lipophilic dioxins accumulate mainly in adipose tissue, this study aimed to determine if dioxins induce metabolic dysfunction in fat cells. Using 3T3-L1 cells as an in vitro model, we analyzed the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a model dioxin, on adipogenic differentiation, glucose uptake, and lipolysis. TCDD inhibited adipogenic differentiation, as determined by using oil droplet… CONTINUE READING

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