Effects of 17beta-estradiol on matrix metalloproteinase-1 synthesis by human dermal fibroblasts.

@article{Qu2006EffectsO1,
  title={Effects of 17beta-estradiol on matrix metalloproteinase-1 synthesis by human dermal fibroblasts.},
  author={LuDan Qu and Masatoshi Abe and Yoko Yokoyama and Osamu Ishikawa},
  journal={Maturitas},
  year={2006},
  volume={54 1},
  pages={39-46}
}
BACKGROUND Hormone replacement therapy (HRT) has been used in treatment of various menopausal disorders. It has been well documented that HRT increases the amount of dermal collagen and skin thickness in vivo. However little is known about the effects of female sex hormones on dermal fibroblasts in vitro. OBJECTIVE The aim of this study is to determine whether or not 17beta-estradiol affects mRNA expression and production of type I collagen, matrix metalloproteinases-1 (MMP-1), tissue… CONTINUE READING

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