Effects of 17beta-estradiol on growth and apoptosis in human vascular endothelial cells: influence of mechanical strain and tumor necrosis factor-alpha.

@article{Ling2006EffectsO1,
  title={Effects of 17beta-estradiol on growth and apoptosis in human vascular endothelial cells: influence of mechanical strain and tumor necrosis factor-alpha.},
  author={Shanhong Ling and Liemin Zhou and He Li and Aozhi Dai and Jun Liu and Paul A Komesaroff and Krishnankutty Sudhir},
  journal={Steroids},
  year={2006},
  volume={71 9},
  pages={799-808}
}
Vascular endothelial cell (EC) integrity is key to arterial health; endothelial dysfunction is linked to atherogenesis. Atherosclerosis shows a male preponderance, possibly related to the protective effect of estrogens in women. This study examined the effect of estrogens on growth, apoptosis and adhesion molecule expression in cultured human EC. The effects of 17beta-estradiol (E2) were studied in human umbilical vein endothelial cells (HUVEC) under normal culture conditions, and following… CONTINUE READING

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