Effects of 16, 16-dimethyl prostaglandin E2 on alkaline secretion in isolated canine gastric mucosa


An isolated fundic mucosal preparation of dog stomach which is capable of exhibiting an alkaline secretion is described. A stable secretion was established 40 min to 1 hr after the mucosa was pretreated with the H2-antagonist cimetidine to block spontaneous acid output. Alkaline secretion decreased when Ca2+ was removed from the nutrient solution. This… (More)
DOI: 10.1007/BF01295812


5 Figures and Tables