Effects of 15d-PGJ₂-loaded poly(D,L-lactide-co-glycolide) nanocapsules on inflammation.

@article{Alves2011EffectsO1,
  title={Effects of 15d-PGJ₂-loaded poly(D,L-lactide-co-glycolide) nanocapsules on inflammation.},
  author={Cf Alves and Nfs de Melo and Lf Fraceto and Dr de Ara{\'u}jo and Mh Napimoga},
  journal={British journal of pharmacology},
  year={2011},
  volume={162 3},
  pages={623-32}
}
BACKGROUND AND PURPOSE The PPAR-γ agonist 15d-PGJ₂ is a potent anti-inflammatory agent but only at high doses. To improve the efficiency of 15d-PGJ₂, we used poly(D,L-lactide-co-glycolide) nanocapsules to encapsulate it, and function as a drug carrier system. The effects of these loaded nanocapsules (15d-PGJ₂-NC) on inflammation induced by different stimuli were compared with those of free 15d-PGJ₂. EXPERIMENTAL APPROACH Mice were pretreated (s.c.) with either 15d-PGJ₂-NC or unloaded 15d-PGJ… CONTINUE READING

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