Effects of 13-nle-motilin in man--inhibition of gastric evacuation and stimulation of pepsin secretion.

@article{Ruppin1975EffectsO1,
  title={Effects of 13-nle-motilin in man--inhibition of gastric evacuation and stimulation of pepsin secretion.},
  author={Hans Ruppin and S. Domschke and Wolfram Domschke and Erick W{\"u}nsch and E. J. J{\"a}ger and L. Demling},
  journal={Scandinavian journal of gastroenterology},
  year={1975},
  volume={10 2},
  pages={199-202}
}
In 3 healthy male volunteers, graded doses of 13-norleucine-motilin (13-nle-motilin)--synthetic analogue of motilin and biologically equivalent to the natural polypeptide--were given intravenously on separate days. Gastric emptying, as determined by means of a radioisotope method, was slowed down dose-dependently by increasing doses of 13-nle-motilin. This was indicated by increasing "half-lives" and "starting indices" of the gastric emptying process, and by decreasing pyloric loss rates… CONTINUE READING

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