Effects of 10 to 30 years of lithium treatment on kidney function

@article{Aiff2015EffectsO1,
  title={Effects of 10 to 30 years of lithium treatment on kidney function},
  author={Harald Aiff and P. O. Attman and Mattias Aurell and Hans Bendz and Bernd Ramsauer and Staffan Sch{\"o}n and Jan Svedlund},
  journal={Journal of Psychopharmacology},
  year={2015},
  volume={29},
  pages={608 - 614}
}
Long-term lithium treatment is associated with end-stage renal disease, but there is little evidence of a clinically significant reduction in renal function in most patients. We previously found that 1.5% of people who took lithium from the 1960s and 1970s developed end-stage renal disease; however, none of the patients who started after 1980 had end-stage renal disease. Here we aimed to study the prevalence and extent of kidney damage during the course of long-term lithium treatment since 1980… 

Figures and Tables from this paper

Chronic kidney disease in lithium-treated patients, incidence and rate of decline
TLDR
The use of lithium seems to be related to a higher incidence of chronic kidney disease, and longer duration of lithium exposure significantly increased the risk of renal failure.
Lithium-Induced Chronic Kidney Disease in a Pediatric Patient
TLDR
The case of a 14-year-old boy who was on lithium for almost 9 years for his complex psychiatric illness and presented with increased urinary frequency and nocturia highlights the fact that lithium-induced chronic kidney disease can present in pediatric age group when lithium is initiated at a young age in children.
Impact of Long-Term Lithium Treatment on Renal Function in Patients With Bipolar Disorder Based on Novel Biomarkers
TLDR
Significant decreased kidney concentrating ability was found in the long-term lithium-treated patients compared with the control group, and other renal function markers did not indicate any significant signs of renal dysfunction.
Estimated glomerular filtration rate in Korean patients exposed to long-term lithium maintenance therapy
TLDR
In Korean patients, treatment with lithium did not increase the risk of developing CKD compared to treatment with valproate and prevalence of CKD was lower than those previously reported in western populations.
Lithium intoxication: Incidence, clinical course and renal function – a population-based retrospective cohort study
TLDR
The aims of this study were to determine the frequency of lithium intoxication and to evaluate the clinical course and changes in renal function, and physicians should have a low threshold to screen for toxicity.
Long-term lithium treatment in bipolar disorder: effects on glomerular filtration rate and other metabolic parameters
TLDR
Long-term lithium treatment wasassociated with gradual decline of renal functioning (eGFR) by about 30% more than that was associated with aging alone, and later low eGFR was also predicted by lower initial eG FR, and starting lithium at age ≥ 40 years.
Compliance with the safety guidelines for long-term lithium treatment in Sweden
TLDR
Compliance with lithium monitoring guidelines improved slowly but steadily over time, and it took three decades to reach a compliance rate of just below 70%.
Endocrinopathies and renal outcomes in lithium therapy: impact of lithium toxicity
TLDR
Assessment of the impact of lithium therapy on the development of endocrine and renal disorders in a cohort of patients in a single tertiary referral centre in Ireland found stage 3 CKD is common in patients receiving lithium therapy.
...
...

References

SHOWING 1-10 OF 21 REFERENCES
Renal insufficiency in long-term lithium treatment.
TLDR
Comparing long-term lithium patients who developed renal insufficiency with those who did not, and to examine what characterized these groups, found RI was associated with episodes of lithium intoxication and diseases or medicines that could affect glomerular function, but not with sex, psychiatric diagnosis, age at onset of diagnosed disorder, duration of lithium therapy, serum lithium concentration, and cumulative lithium dose.
Kidney damage in long-term lithium patients: a cross-sectional study of patients with 15 years or more on lithium.
TLDR
It is concluded that kidney damage is common in patients on long-term lithium treatment and that both glomerular and tubular function are affected.
Effects of chronic lithium treatment on renal function.
Lithium-induced nephropathy: Rate of progression and prognostic factors.
TLDR
Lithium-induced chronic renal disease is slowly progressive and its rate of progression is related to the duration of lithium administration, which represents 0.22% of all causes of ESRD in France.
The Impact Of Long-Term Lithium Treatment On Renal Function In An Outpatient Population
TLDR
It is concluded that lithium can be safely prescribed over a protracted period of time, even in elderly populations, but should be monitored closely under specialist supervision, to ensure early identification and management of adverse effects.
End-stage renal disease associated with prophylactic lithium treatment
Monitoring of glomerular filtration rate in lithium-treated outpatients--an ambulatory laboratory database surveillance.
TLDR
A very high percentage of Li-treated outpatients have low eGFR, and GFR monitoring is neglected in these patients, the majority of whom are no longer attending specialized clinics.
Renal Failure in Lithium-Treated Bipolar Disorder: A Retrospective Cohort Study
TLDR
Lithium is associated with an increased risk of renal failure, particularly among the older age group, and the absolute risk of kidney failure associated with lithium use remains small.
Premature cardiovascular disease in chronic renal failure
...
...