Effects of 1 to 3 years' treatment with alendronate on mechanical properties of the femoral shaft in a canine model: implications for subtrochanteric femoral fracture risk.

@article{Burr2009EffectsO1,
  title={Effects of 1 to 3 years' treatment with alendronate on mechanical properties of the femoral shaft in a canine model: implications for subtrochanteric femoral fracture risk.},
  author={David B. Burr and Tamim Diab and Andrew Koivunemi and Mark Koivunemi and Matthew R Allen},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2009},
  volume={27 10},
  pages={1288-92}
}
Bisphosphonate (BP) treatment used to prevent bone loss in postmenopausal osteoporosis has recently been implicated in an apparent increase in subtrochanteric femoral fractures. Previous work showed that BPs can reduce the energy to fracture of cancellous bone, but limited data exist on material-level mechanical properties of compact bone from the long bones. This study examined intrinsic mechanical properties of the femoral diaphysis of a canine model treated for 1 or 3 years with alendronate… CONTINUE READING
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