Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion.

@article{Bates1994EffectsO1,
  title={Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion.},
  author={Timothy Edward Bates and Simon J. R. Heales and Si{\^a}n E. C. Davies and P Boakye and John Bates Clark},
  journal={Journal of neurochemistry},
  year={1994},
  volume={63 2},
  pages={640-8}
}
The effects of 1-methyl-4-phenylpyridinium (MPP+) on the oxygen consumption, ATP production, H2O2 production, and mitochondrial NADH-CoQ1 reductase (complex I) activity of isolated rat brain mitochondria were investigated. Using glutamate and malate as substrates, concentrations of 10-100 microM MPP+ had no effect on state 4 (-ADP) respiration but decreased state 3 (+ADP) respiration and ATP production. Incubating mitochondria with ADP for 30 min after loading with varying concentrations of MPP… CONTINUE READING

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