Effects of 1-beta-D-arabinofuranosylcytosine incorporation on eukaryotic DNA template function.

@article{Kufe1984EffectsO1,
  title={Effects of 1-beta-D-arabinofuranosylcytosine incorporation on eukaryotic DNA template function.},
  author={Donald Kufe and David R. Munroe and David J Herrick and E. Michael Egan and David S. Spriggs},
  journal={Molecular pharmacology},
  year={1984},
  volume={26 1},
  pages={128-34}
}
1-beta-D-Arabinofuranosylcytosine (ara-C) incorporates into DNA, and the extent of this incorporation correlates significantly with inhibition of DNA synthesis. The incorporated ara-C residue provides a poor primer terminus for further chain elongation. There is a highly significant relationship between formation of (ara-C) DNA and loss of clonogenic survival. The present studies confirm that incorporation of ara-C into DNA, and not the competitive inhibition of DNA polymerase, is responsible… CONTINUE READING

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