Effects of 1,4-butanediol administration on oxidative stress in rat brain: Study of the neurotoxicity of γ-hydroxybutyric acid in vivo

@article{Sgaravatti2009EffectsO1,
  title={Effects of 1,4-butanediol administration on oxidative stress in rat brain: Study of the neurotoxicity of γ-hydroxybutyric acid in vivo},
  author={{\^A}. M. Sgaravatti and A. Magnusson and A. S. Oliveira and C. Mescka and F. Zanin and M. B. Sgarbi and C. D. Pederzolli and A. Wyse and C. Wannmacher and M. Wajner and C. Dutra-Filho},
  journal={Metabolic Brain Disease},
  year={2009},
  volume={24},
  pages={271-282}
}
  • Â. M. Sgaravatti, A. Magnusson, +8 authors C. Dutra-Filho
  • Published 2009
  • Chemistry, Medicine
  • Metabolic Brain Disease
  • Abstractγ-Hydroxybutyric acid (GHB) is a naturally occurring compound in the central nervous system (CNS) whose tissue concentration are highly increased in the neurometabolic-inherited deficiency of succinic semialdehyde dehydrogenase (SSADH) activity or due to intoxication. SSADH deficiency is biochemically characterized by increased concentrations of GHB in tissues, cerebrospinal fluid, blood and urine of affected patients. Clinical manifestations are variable and include retardation of… CONTINUE READING
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    References

    SHOWING 1-10 OF 59 REFERENCES
    γ-Hydroxybutyric acid induces oxidative stress in cerebral cortex of young rats
    • 43
    Significance of γ-hydroxybutyric acid in the brain
    • 82
    Evidence for oxidative stress in tissues derived from succinate semialdehyde dehydrogenase-deficient mice
    • 33
    Central effects of 1,4-butanediol are mediated by GABA(B) receptors via its conversion into gamma-hydroxybutyric acid.
    • 18
    Inhibition of succinic semialdehyde dehydrogenase activity by alkenal products of lipid peroxidation.
    • 47
    Murine succinate semialdehyde dehydrogenase deficiency
    • 51
    Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal.
    • 2,806
    Evidence that central nervous system depression by 1,4-butanediol in mediated through a metabolite, gamma-hydroxybutyrate.
    • 79