Effects of 1,4-butanediol administration on oxidative stress in rat brain: Study of the neurotoxicity of γ-hydroxybutyric acid in vivo

@article{Sgaravatti2009EffectsO1,
  title={Effects of 1,4-butanediol administration on oxidative stress in rat brain: Study of the neurotoxicity of $\gamma$-hydroxybutyric acid in vivo},
  author={{\^A}ngela Malysz Sgaravatti and Alessandra Selinger Magnusson and Amanda S. Oliveira and Caroline Paula Mescka and Fernanda Rech Zanin and Mirian Bonaldi Sgarbi and Carolina Didonet Pederzolli and Angela T.S. Wyse and Clovis Milton Duval Wannmacher and Moacir Wajner and Carlos Severo Dutra-filho},
  journal={Metabolic Brain Disease},
  year={2009},
  volume={24},
  pages={271-282}
}
Abstractγ-Hydroxybutyric acid (GHB) is a naturally occurring compound in the central nervous system (CNS) whose tissue concentration are highly increased in the neurometabolic-inherited deficiency of succinic semialdehyde dehydrogenase (SSADH) activity or due to intoxication. SSADH deficiency is biochemically characterized by increased concentrations of GHB in tissues, cerebrospinal fluid, blood and urine of affected patients. Clinical manifestations are variable and include retardation of… 

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