Effects of 1,4-butanediol administration on oxidative stress in rat brain: Study of the neurotoxicity of γ-hydroxybutyric acid in vivo

@article{Sgaravatti2009EffectsO1,
  title={Effects of 1,4-butanediol administration on oxidative stress in rat brain: Study of the neurotoxicity of γ-hydroxybutyric acid in vivo},
  author={{\^A}. M. Sgaravatti and A. Magnusson and A. S. Oliveira and C. Mescka and F. Zanin and M. B. Sgarbi and C. D. Pederzolli and A. Wyse and C. Wannmacher and M. Wajner and C. Dutra-Filho},
  journal={Metabolic Brain Disease},
  year={2009},
  volume={24},
  pages={271-282}
}
  • Â. M. Sgaravatti, A. Magnusson, +8 authors C. Dutra-Filho
  • Published 2009
  • Chemistry, Medicine
  • Metabolic Brain Disease
    • Abstractγ-Hydroxybutyric acid (GHB) is a naturally occurring compound in the central nervous system (CNS) whose tissue concentration are highly increased in the neurometabolic-inherited deficiency of succinic semialdehyde dehydrogenase (SSADH) activity or due to intoxication. SSADH deficiency is biochemically characterized by increased concentrations of GHB in tissues, cerebrospinal fluid, blood and urine of affected patients. Clinical manifestations are variable and include retardation of… CONTINUE READING
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