Effects of (−)‐Sulpiride on Dopamine Release in Striatum of Developing Rats: Degree of Depolarization Influences Responsiveness

  title={Effects of (−)‐Sulpiride on Dopamine Release in Striatum of Developing Rats: Degree of Depolarization Influences Responsiveness},
  author={Susan L Andersen and Russell A. Gazzara},
  journal={Journal of Neurochemistry},
Abstract: The purpose of this study was to determine the effects of localized delivery of the D2 antagonist (−)‐sulpiride (via microdialysis) on spontaneous and evoked dopamine release in the neostriatum of urethane‐anesthetized rats 5, 10, 15, 21, and 70 days of age. Sulpiride increased spontaneous dopamine release approximately threefold relative to baseline measures, and this effect decreased with maturation. The relationship between sulpiride‐ and potassium‐evoked release was complex… 
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