Effects of (+)-propranolol on intracellular mechanisms of contraction in striated muscle of the rabbit

@article{Su2004EffectsO,
  title={Effects of (+)-propranolol on intracellular mechanisms of contraction in striated muscle of the rabbit},
  author={Judy Y. Su and Dean Anthony Malencik},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={331},
  pages={194-201}
}
  • Judy Y. Su, D. Malencik
  • Published 1 November 1985
  • Biology, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
SummaryIn functionally skinned muscle fibers from the rabbit, we studied the effect of propranolol on calcium activation of the contractile proteins and, in separate experiments, on calcium uptake and release from the sarcoplasmic reticulum (SR) while measuring physiological tension. Pieces from isolated papillary muscle (PM), soleus (SL) (slowtwitch skeletal muscle), and adductor magnus (AM) (fasttwitch skeletal muscle) were homogenized (sarcolemma disrupted). A fiber bundle from PM and single… 
Contrasting effects of betaxolol and propranolol on Ca2+-activated contractions in skinned fibers from canine coronary arteries and ventricular muscles
  • Y. Kitada
  • Biology
    Cardiovascular Drugs and Therapy
  • 2004
TLDR
It is indicated that among beta-adrenoceptor antagonists, only betaxolol and propranolol can directly modulate the Ca2+ sensitivity of myofilaments and have opposite effects on the contractile system in canine cardiac and vascular smooth muscle.
Skeletal muscle contractility : The role of nitric-oxide system and beta-adrenoceptors
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The role of substances with beta agonistic activity was investigated in order to discover possibilities in the therapy of muscle wasting conditions and the interaction between substances which modulate NO system activity and cAMP levels in the skeletal muscle.
The influence of lidocaine and beta-blockers on L-NAME-induced potentiation of the isolated rat hemidiaphragm contractility
TLDR
The aim of this study was to investigate the possible modulatory effect of local anaesthetic (lidocaine) and beta adrenergic blockers, propranolol and atenolol, on the L-NAME- induced potentiation of isometric contractility (1C).
Intracellular mechanisms of verapamil and diltiazem action on striated muscle of the rabbit
  • Judy Y. Su
  • Biology, Chemistry
    Naunyn-Schmiedeberg's Archives of Pharmacology
  • 2004
TLDR
VP and DT have similar intracellular mechanisms of action in striated muscle that induce calcium release from the SR and increase Ca2+ sensitivity of the contractile proteins, and thus could be the underlying mechanisms for potentiating twitch tension, and inducing contracture in skeletal muscle.

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