Effects of (+)-propranolol on intracellular mechanisms of contraction in striated muscle of the rabbit

  title={Effects of (+)-propranolol on intracellular mechanisms of contraction in striated muscle of the rabbit},
  author={Judy Y. Su and Dean Anthony Malencik},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  • Judy Y. Su, D. Malencik
  • Published 1 November 1985
  • Biology, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
SummaryIn functionally skinned muscle fibers from the rabbit, we studied the effect of propranolol on calcium activation of the contractile proteins and, in separate experiments, on calcium uptake and release from the sarcoplasmic reticulum (SR) while measuring physiological tension. Pieces from isolated papillary muscle (PM), soleus (SL) (slowtwitch skeletal muscle), and adductor magnus (AM) (fasttwitch skeletal muscle) were homogenized (sarcolemma disrupted). A fiber bundle from PM and single… 
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Mechanism of propranolol inhibition of the cardiac sarcotubule-γ-AT32P reaction
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