Effects of ω-3 PUFA and ascorbic acid combination on post-resuscitation myocardial function.

  title={Effects of $\omega$-3 PUFA and ascorbic acid combination on post-resuscitation myocardial function.},
  author={Cheng Cheng and Hui Li and Lian Liang and Tao Jin and Guozhen Zhang and Jennifer L. Bradley and Mary Ann A Peberdy and Joseph P. Ornato and Dayanjan Shanaka Wijesinghe and Wanchun Tang},
  journal={Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  • Cheng Cheng, Hui Li, Wanchun Tang
  • Published 6 November 2020
  • Biology, Medicine
  • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
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Targeting Ferroptosis against Ischemia/Reperfusion Cardiac Injury
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Imbalance of GM and microbial dysfunction are involved in aggravated thromboembolic risk of AF, and the KEGG orthology-based scoring approach exhibited a significant association with thrombolic risk in AF patients.
Vitamin C May Improve Left Ventricular Ejection Fraction: A Meta-Analysis
A meta-analysis looks at the effect of vitamin C on left ventricular ejection fraction (LVEF) in both cardiac and non-cardiac patients, with a strong negative association between the size of the vitamin C effect and the baseline LVEF.
Pharmacological Approach for Neuroprotection After Cardiac Arrest—A Narrative Review of Current Therapies and Future Neuroprotective Cocktail
A narrative review seeks to highlight the current field of post-CA neuroprotective pharmaceutical therapies, both singular and combination, and discuss the use of an extensive multi-drug cocktail therapy as a novel approach to treat CA-mediated dysregulation of multiple pathways, enhancing survival, and neuroprotection.


Polyunsaturated fatty acid induces cardioprotection against ischemia-reperfusion through the inhibition of NF-kappaB and induction of Nrf2
Test cardioprotective mechanisms induced by PUFA supplementation against cardiac ischemia-reperfusion injury showed lower IS and a higher LVDP compared with the nonsupplemented rats, indicating induction of anti-inflammatory and antioxidant mechanism at tissue level.
n-3 PUFA Induce Microvascular Protective Changes During Ischemia/Reperfusion
Consumption of n-3 polyunsaturated fatty acids, especially in the triacylglycerol form, could be a promising therapy to prevent microvascular damage induced by ischemia/reperfusion and its consequent clinical sequelae.
Cardioprotective effects of omega-3 fatty acids and ascorbic acid improve regenerative capacity of embryonic stem cell-derived cardiac lineage cells.
Evidence is provided that EPA’s DHA and AA may be an appropriate preincubation regimen for regenerative purposes and that an injection of ESC-derived cardiac lineage cells into the ischemic myocardium of a rat model of MI significantly reduced fibrosis compared to the vehicle group.
Cannabinoid Receptor Agonist WIN55, 212-2 Adjusts Lipid Metabolism in a Rat Model of Cardiac Arrest.
Postresuscitation hypothermia improved myocardial function and microcirculation and WH-mediated lipid metabolism had the best metabolic outcome to bring back the animals to normal metabolism, which may be protective to improve outcomes of CA.
Anti-Oxidative Effects of Melatonin Receptor Agonist and Omega-3 Polyunsaturated Fatty Acids in Neuronal SH-SY5Y Cells: Deciphering Synergic Effects on Anti-Depressant Mechanisms
The results demonstrated that RMT and EPA synergistically provide effective neuroprotective, anti-oxidative/inflammatory effect against oxidative stress, and provides pre-clinical evidence to conduct future clinical trials of using n-3 PUFAs/RMT combination in depressive disorders.
Vitamin E supplementation modulates the biological effects of omega-3 fatty acids in naturally aged rats
It was found that in omega-3 fats alone consumed rats the lipid profile was improved, while in Omega-3 fat with vitamin-E-consumed group (OMVE), the hepato protective and antioxidant properties were pronounced, especially the redox status of brain tissue.
Combination of intravenous ascorbic acid administration and hypothermia after resuscitation improves myocardial function and survival in a ventricular fibrillation cardiac arrest model in the rat.
Intravenous ascorbic acid administration after ROSC in normothermia may mitigate myocardial damage and improve systolic function, survival rate, and neurologic outcomes in VF cardiac arrest of rat.
The combined effect of vitamin C and omega-3 polyunsaturated fatty acids on fatigue following coronary artery bypass graft surgery: a triple-blind clinical trial
Combination of vitamin C and n-3 PUFA effectively reduces post-operative fatigue among patients who undergo CABG surgery.
Early Protection Against Sudden Death by n-3 Polyunsaturated Fatty Acids After Myocardial Infarction Time-Course Analysis of the Results of the Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico (GISSI)-Prevenzione
Survition curves for n-3 PUFA treatment diverged early after randomization, and total mortality was significantly lowered after 3 months of treatment (relative risk [RR] 0...