Effects of ω-3 PUFA and ascorbic acid combination on post-resuscitation myocardial function.
@article{Cheng2020EffectsO, title={Effects of $\omega$-3 PUFA and ascorbic acid combination on post-resuscitation myocardial function.}, author={Cheng Cheng and Hui Li and Lian Liang and Tao Jin and Guozhen Zhang and Jennifer L. Bradley and Mary Ann A Peberdy and Joseph P. Ornato and Dayanjan Shanaka Wijesinghe and Wanchun Tang}, journal={Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie}, year={2020}, volume={133}, pages={ 110970 } }
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References
SHOWING 1-10 OF 32 REFERENCES
Polyunsaturated fatty acid induces cardioprotection against ischemia-reperfusion through the inhibition of NF-kappaB and induction of Nrf2
- BiologyExperimental biology and medicine
- 2017
Test cardioprotective mechanisms induced by PUFA supplementation against cardiac ischemia-reperfusion injury showed lower IS and a higher LVDP compared with the nonsupplemented rats, indicating induction of anti-inflammatory and antioxidant mechanism at tissue level.
n-3 PUFA Induce Microvascular Protective Changes During Ischemia/Reperfusion
- BiologyLipids
- 2014
Consumption of n-3 polyunsaturated fatty acids, especially in the triacylglycerol form, could be a promising therapy to prevent microvascular damage induced by ischemia/reperfusion and its consequent clinical sequelae.
Cardioprotective effects of omega-3 fatty acids and ascorbic acid improve regenerative capacity of embryonic stem cell-derived cardiac lineage cells.
- Biology, MedicineBioFactors
- 2019
Evidence is provided that EPA’s DHA and AA may be an appropriate preincubation regimen for regenerative purposes and that an injection of ESC-derived cardiac lineage cells into the ischemic myocardium of a rat model of MI significantly reduced fibrosis compared to the vehicle group.
Cannabinoid Receptor Agonist WIN55, 212-2 Adjusts Lipid Metabolism in a Rat Model of Cardiac Arrest.
- Medicine, BiologyTherapeutic hypothermia and temperature management
- 2020
Postresuscitation hypothermia improved myocardial function and microcirculation and WH-mediated lipid metabolism had the best metabolic outcome to bring back the animals to normal metabolism, which may be protective to improve outcomes of CA.
Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids.
- BiologyThe Journal of nutritional biochemistry
- 2010
Anti-Oxidative Effects of Melatonin Receptor Agonist and Omega-3 Polyunsaturated Fatty Acids in Neuronal SH-SY5Y Cells: Deciphering Synergic Effects on Anti-Depressant Mechanisms
- BiologyMolecular Neurobiology
- 2018
The results demonstrated that RMT and EPA synergistically provide effective neuroprotective, anti-oxidative/inflammatory effect against oxidative stress, and provides pre-clinical evidence to conduct future clinical trials of using n-3 PUFAs/RMT combination in depressive disorders.
Vitamin E supplementation modulates the biological effects of omega-3 fatty acids in naturally aged rats
- BiologyToxicology mechanisms and methods
- 2017
It was found that in omega-3 fats alone consumed rats the lipid profile was improved, while in Omega-3 fat with vitamin-E-consumed group (OMVE), the hepato protective and antioxidant properties were pronounced, especially the redox status of brain tissue.
Combination of intravenous ascorbic acid administration and hypothermia after resuscitation improves myocardial function and survival in a ventricular fibrillation cardiac arrest model in the rat.
- Medicine, BiologyAcademic emergency medicine : official journal of the Society for Academic Emergency Medicine
- 2014
Intravenous ascorbic acid administration after ROSC in normothermia may mitigate myocardial damage and improve systolic function, survival rate, and neurologic outcomes in VF cardiac arrest of rat.
The combined effect of vitamin C and omega-3 polyunsaturated fatty acids on fatigue following coronary artery bypass graft surgery: a triple-blind clinical trial
- MedicineJournal of complementary & integrative medicine
- 2019
Combination of vitamin C and n-3 PUFA effectively reduces post-operative fatigue among patients who undergo CABG surgery.
Early Protection Against Sudden Death by n-3 Polyunsaturated Fatty Acids After Myocardial Infarction Time-Course Analysis of the Results of the Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico (GISSI)-Prevenzione
- Medicine
- 2002
Survition curves for n-3 PUFA treatment diverged early after randomization, and total mortality was significantly lowered after 3 months of treatment (relative risk [RR] 0...