Effects of β-blockers and tricyclic antidepressants on the activity of human organic anion transporting polypeptide 1A2 (OATP1A2).

@article{Lu2015EffectsO,
  title={Effects of β-blockers and tricyclic antidepressants on the activity of human organic anion transporting polypeptide 1A2 (OATP1A2).},
  author={Jennifer Lu and Veronique Michaud and Liliam Gabriela Guilarte Moya and Fleur Gaudette and Yat Hei Leung and Jacques Turgeon},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2015},
  volume={352 3},
  pages={
          552-8
        }
}
The organic anion transporting polypeptide 1A2 (OATP1A2), a membrane drug transporter expressed on important organs (such as the brain, kidney, and intestine) may be a key element in the disposition of drugs. Previous studies demonstrated that it could transport a broad spectrum of substrates, including endogenous molecules and clinically relevant drugs, such as several β-blockers and 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors. The primary objective of this study was to investigate… CONTINUE READING

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