Effects of β-adrenoceptor stimulation on delayed rectifier K(+) currents in canine ventricular cardiomyocytes.

@article{Harmati2011EffectsO,
  title={Effects of β-adrenoceptor stimulation on delayed rectifier K(+) currents in canine ventricular cardiomyocytes.},
  author={G{\'a}bor Harmati and Tam{\'a}s B{\'a}ny{\'a}sz and L{\'a}szl{\'o} B{\'a}r{\'a}ndi and Norbert Szentandr{\'a}ssy and Bal{\'a}zs Horv{\'a}th and G{\'a}bor Szab{\'o} and J{\'o}zsef A Szentmikl{\'o}si and G{\'a}bor Sz{\'e}n{\'a}si and P{\'e}ter P{\'a}l N{\'a}n{\'a}si and J{\'a}nos Magyar},
  journal={British journal of pharmacology},
  year={2011},
  volume={162 4},
  pages={890-6}
}
BACKGROUND AND PURPOSE While the slow delayed rectifier K(+) current (I(Ks)) is known to be enhanced by the stimulation of β-adrenoceptors in several mammalian species, phosphorylation-dependent regulation of the rapid delayed rectifier K(+) current (I(Kr)) is controversial. EXPERIMENTAL APPROACH In the present study, therefore, the effect of isoprenaline (ISO), activators and inhibitors of the protein kinase A (PKA) pathway on I(Kr) and I(Ks) was studied in canine ventricular myocytes using… CONTINUE READING