Effects of β-adrenoceptor antagonists on alcohol drinking by alcohol-dependent rats

@article{Gilpin2010EffectsO,
  title={Effects of β-adrenoceptor antagonists on alcohol drinking by alcohol-dependent rats},
  author={Nicholas W Gilpin and George F. Koob},
  journal={Psychopharmacology},
  year={2010},
  volume={212},
  pages={431-439}
}
Alcohol-dependent animals display enhanced stress responsivity, reward thresholds, and alcohol self-administration during alcohol withdrawal, and some of these aspects of alcohol dependence may be mediated by activation of brain norepinephrine (NE) systems. This study examined the effects of propranolol, a β-adrenoceptor antagonist, on operant alcohol-reinforced responding by alcohol-dependent and non-dependent rats. Adult male Wistar rats were trained to respond for alcohol in an operant… CONTINUE READING
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