Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice

Abstract

Current antipsychotic drugs (APDs) show efficacy with positive symptoms, but are limited in treating negative or cognitive features of schizophrenia. Whereas all currently FDA-approved medications target primarily the dopamine D2 receptor (D2R) to inhibit Gi/o-mediated adenylyl cyclase, a recent study has shown that many APDs affect not only Gi/o- but they… (More)
DOI: 10.1038/npp.2015.196

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Cite this paper

@article{Park2016EffectsO, title={Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice}, author={Su Mi Park and Meng Chen and Claire M. Schmerberg and Russell S Dulman and Ramona Marie Rodriguiz and Marc G. Caron and Jian Jin and William C. Wetsel}, journal={Neuropsychopharmacology}, year={2016}, volume={41}, pages={704-715} }