Effects of α-tubulin K40 acetylation and detyrosination on kinesin-1 motility in a purified system.

@article{Kaul2014EffectsO,
  title={Effects of α-tubulin K40 acetylation and detyrosination on kinesin-1 motility in a purified system.},
  author={Neha Kaul and Virupakshi Soppina and Kristen J Verhey},
  journal={Biophysical journal},
  year={2014},
  volume={106 12},
  pages={2636-43}
}
Long-range transport in cells is achieved primarily through motor-based transport along a network of microtubule tracks. Targeted transport by kinesin motors can be correlated with posttranslational modifications (PTMs) of the tubulin subunits in specific microtubules. To directly examine the influence of specific PTMs on kinesin-1 motility, we generated tubulin subunits that were either enriched in or lacking acetylation of α-tubulin lysine 40 (K40) or detyrosination of the α-tubulin C… CONTINUE READING
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