Effects of α-tocopherol (Vitamin E) on the Ultrastructure of Human Platelets In Vitro.

Washed human platelets were incubated with increasing concentrations of α-tocopherol. Spontaneous aggregation was induced by tocopherol (0.5 mM or above). Aggregation was inhibited by ethylenediaminetetraacetate and platelet activation was reduced by prostaglandin E(1). Using electron microscopy, it was confirmed that tocopherol caused platelet disruption… CONTINUE READING