Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in prenatal stage on the dopamine system in the postnatal mouse brain.

@article{Ochi1991EffectsO1,
  title={Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in prenatal stage on the dopamine system in the postnatal mouse brain.},
  author={Nobuhiko Ochi and Makato Naoi and Makio Mogi and Yusuke Ohya and Nobuhiko Mizutani and Kazuo Watanabe and Masaki Harada and Toshiharu Toshi Nagatsu},
  journal={Life sciences},
  year={1991},
  volume={48 3},
  pages={
          217-23
        }
}
A dopaminergic neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (MPTP), administered to a pregnant female was found to affect postnatally the catecholamine metabolism of the pups. MPTP (5 mg/kg body weight/day) was administered to pregnant C57 Black BYA mice daily for 7 days between the 12th and 18th day of gestation. Dopamine levels and tyrosine… CONTINUE READING