Effects of (+)-methamphetamine on path integration and spatial learning, but not locomotor activity or acoustic startle, align with the stress hyporesponsive period in rats

@article{Vorhees2009EffectsO,
  title={Effects of (+)-methamphetamine on path integration and spatial learning, but not locomotor activity or acoustic startle, align with the stress hyporesponsive period in rats},
  author={Charles V Vorhees and M R Skelton and Curtis E. Grace and Tori L. Schaefer and Michael T Williams},
  journal={International Journal of Developmental Neuroscience},
  year={2009},
  volume={27},
  pages={289-298}
}
Rats treated with (+)-methamphetamine (MA) on postnatal days (P) 11-20 exhibit long-term spatial and path integration (Morris water maze (MWM) and Cincinnati water maze (CWM)) learning deficits whereas those treated on P1-10 do not. MA treatment increases corticosterone release in an age-dependent U-shaped pattern that corresponds to the stress hyporesponsive period (SHRP; P4-15). Here we tested the hypothesis that the cognitive effects induced by MA are associated with treatment that begins… CONTINUE READING

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