Effects in vitro and in vivo by apomorphine in the rat corpus cavernosum.

@article{Matsumoto2005EffectsIV,
  title={Effects in vitro and in vivo by apomorphine in the rat corpus cavernosum.},
  author={Kenshi Matsumoto and Masaki Yoshida and K -E Andersson and Petter Hedlund},
  journal={British journal of pharmacology},
  year={2005},
  volume={146 2},
  pages={259-67}
}
The study was performed to clarify if apomorphine at the level of the rat corpus cavernosum can produce erectile responses or interfere with nerve-induced penile erection. Apomorphine (10(-9)-10(-4) M) exhibited a 10-fold higher potency to relax phenylephrine (Phe)- than endothelin-1 (ET-1)-induced contractions. Relaxant effects of apomorphine in Phe-activated corpus cavernosum did not change tissue levels of cyclic nucleotides, and were unaffected by inhibition of the synthesis of nitric oxide… CONTINUE READING

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