Effects from metal ion in tumor endothelial marker 8 and anthrax protective antigen: BioLayer Interferometry experiment and molecular dynamics simulation study

@article{Jia2017EffectsFM,
  title={Effects from metal ion in tumor endothelial marker 8 and anthrax protective antigen: BioLayer Interferometry experiment and molecular dynamics simulation study},
  author={Zhe Jia and Christine Ackroyd and Tingting Han and Vibhor Agrawal and Yinling Liu and Kenneth Christensen and Brian Dominy},
  journal={Journal of computational chemistry},
  year={2017},
  volume={38 15},
  pages={1183-1190}
}
One of the anthrax receptors, tumor endothelial marker 8 (TEM8), is reported to be a potential anticancer target due to its over-expression during tumor angiogenesis. To extend our BioLayer Interferometry study in PA-TEM8 binding, we present a computational approach to reveal the role of an integral metal ion on receptor structure and binding thermodynamics… CONTINUE READING