Effects and side‐effects of 2% progesterone cream on the skin of peri‐ and postmenopausal women: results from a double‐blind, vehicle‐controlled, randomized study

  title={Effects and side‐effects of 2\% progesterone cream on the skin of peri‐ and postmenopausal women: results from a double‐blind, vehicle‐controlled, randomized study},
  author={Gregor Holzer and Elisabeth Riegler and Herbert H{\"o}nigsmann and Sahar Farokhnia and B. Schmidt},
  journal={British Journal of Dermatology},
Background  For many years topical progesterone has been prescribed by gynaecologists as an antiageing and skin‐firming treatment, without any clinical scientific evidence of its effects, tolerability and safety when applied to skin. 

Transdermal natural progesterone cream for postmenopausal women: Inconsistent data and complex pharmacokinetics

  • M. ElshafieA. Ewies
  • Medicine, Biology
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
  • 2007
Given the current best available evidence, using PC for postmenopausal therapy regimens should be considered as an unsubstantiated treatment option, and its clinical applications must be restricted to well-designed interventional trials that assess its efficacy and safety.

Effects of topical estradiol on the facial skin collagen of postmenopausal women under oral hormone therapy: a pilot study.

Impact of progesterone on skin and hair in menopause – a comprehensive review

Delays of skin aging comprises lifestyle adjustment, antioxidants, and several esthetic procedures, and in menopausal women, MHT displays beneficial effects on skin aging.

Compatibility of Personalized Formulations in Cleoderm™, A Skin Rebalancing Cream Base for Oily and Sensitive Skin

It is concluded that Cleoderm™ presents increased convenience for both the compounding pharmacist and the patient, suggesting that it is an adequate candidate vehicle for compounding different dermatological formulations with adequate stability, presenting itself as a good alternative to commercially available treatments that cannot be personalized.

Community Pharmacists' Therapeutic Recommendations for Heavy Flow, Androgen Excess, Fragility Fractures and Night Sweats in Menstruating Women

Community pharmacists vary widely in their treatment choices for common pre- and perimenopausal women's menstrual cycle–related problems, and the evidence in support of most recommendations is minimal or lacking.

Menopause and skin aging

Although skin aging is certainly no indication for the hormone replacement therapy the beneficial effect of estrogen supplementation on the skin appearance is a positive side aspect of such treatment.

Potential adverse effects of prophylactic bilateral salpingo-oophorectomy on skin aging in premenopausal women undergoing hysterectomy for benign conditions

Prophylactic BSO in the presence of dermatological conditions is a significant independent risk factor for worsening skin laxity/sagging and texture/dryness in premenopausal women undergoing hysterectomy for benign conditions.



A study to evaluate serum and urinary hormone levels following short and long term administration of two regimens of progesterone cream in postmenopausal women

The pharmacokinetics of a progesterone cream following short and long term dermal administration are studied to determine the pharmacokinetic properties of the cream and to determine its application in the vaginal and laparoscopic setting.

The effect of topical oestradiol on skin collagen of postmenopausal women

The objective to examine the effect of topical oestradiol on skin collagen and elastin and to propose a new drug to treat eczema.


Investigation of whether topical treatment of the skin with estrogen could reverse some of the changes in the aging skin found in the perimenopausal woman.

Effect of Hormone Replacement Therapy for Menopause on the Mechanical Properties of Skin

Evaluation of the effect of hormone replacement therapy for menopause on the mechanical properties of the skin in healthy women finds no significant difference in the quality of life for women who have had HRT.

Long‐term effects of the menopause and sex hormones on skin thickness

The data suggest that skin collagen is influenced by the sex hormone status arid declines after the menopause contributing to the increase in urinary hydroxyproline excretion that has been reported to occur this time.