Effects and molecular mechanisms of the antidiabetic fraction of Acorus calamus L. on GLP-1 expression and secretion in vivo and in vitro.

@article{Liu2015EffectsAM,
  title={Effects and molecular mechanisms of the antidiabetic fraction of Acorus calamus L. on GLP-1 expression and secretion in vivo and in vitro.},
  author={Yun-Xi Liu and Mei-mei Si and Wei Lu and Li-xia Zhang and Chang-xin Zhou and Shu-li Deng and Hao-Shu Wu},
  journal={Journal of ethnopharmacology},
  year={2015},
  volume={166},
  pages={168-75}
}
ETHNOPHARMACOLOGICAL RELEVANCE The radix of Acorus calamus L. (AC) is widely used in diabetes therapies in traditional folk medicine from America and Indonesia, and we have previously reported that the ethyl acetate fraction of AC (ACE) acts as an antidiabetic through insulin sensitizing, insulin releasing and alpha-glucosidase inhibitory activities. The present study is designed to investigate the effects and molecular mechanisms of ACE on glucagon-like peptide-1 (GLP-1) expression and… CONTINUE READING