Effects and mechanisms of store-operated calcium channel blockade on hepatic ischemia-reperfusion injury in rats.

@article{Pan2012EffectsAM,
  title={Effects and mechanisms of store-operated calcium channel blockade on hepatic ischemia-reperfusion injury in rats.},
  author={Li-Jie Pan and Zi-Chao Zhang and Zhen-ya Zhang and Wenjun Wang and Y. L. Xu and Zong-ming Zhang},
  journal={World journal of gastroenterology},
  year={2012},
  volume={18 4},
  pages={356-67}
}
AIM To further investigate the important role of store-operated calcium channels (SOCs) in rat hepatocytes and to explore the effects of SOC blockers on hepatic ischemia-reperfusion injury (HIRI). METHODS Using freshly isolated hepatocytes from a rat model of HIRI (and controls), we measured cytosolic free Ca(2+) concentration (by calcium imaging), net Ca(2+) fluxes (by a non-invasive micro-test technique), the SOC current (I(SOC); by whole-cell patch-clamp recording), and taurocholate… CONTINUE READING