Effects and interaction studies of triflusal and other salicylic derivatives on cyclooxygenase in rats.

@article{deCastellarnau1988EffectsAI,
  title={Effects and interaction studies of triflusal and other salicylic derivatives on cyclooxygenase in rats.},
  author={C de Castellarnau and Mar{\'i}a J. Sancho and Luis Vila and M Albors and Miquel Rutllant},
  journal={Prostaglandins, leukotrienes, and essential fatty acids},
  year={1988},
  volume={31 2},
  pages={
          83-9
        }
}
Triflusal (TR) is a new salicylic acid derivative used clinically as an antiplatelet drug. Both aspirin (ASA) and TR inhibit platelet cyclooxygenase but the effects of these drugs are different. TR (0.5-2 mM) strongly inhibited platelet aggregation and malondialdehyde formation induced by arachidonic acid. The IC50 was 0.8 mM for TR and less than 0.1 mM for ASA. Deacetylated compounds, salicylic acid (SA) and HTB (the main metabolite of TR) were apparently competitive and reversible inhibitors… Expand
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