Effects and aftereffects of ibogaine on morphine self-administration in rats.

  title={Effects and aftereffects of ibogaine on morphine self-administration in rats.},
  author={Stanley D. Glick and K. Rossman and Sally Steindorf and Isabelle M. Maisonneuve and Jeffrey N. Carlson},
  journal={European journal of pharmacology},
  volume={195 3},

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Short communication Ibogaine-like effects of noribogaine in rats

Noribogaine (40 mg/kg) was found to decrease morphine and cocaine self-administration, reduce the locomotor stimulant effect of morphine, and decrease extracellular levels of dopamine in the nucleus accumbens and stiiatum; however, noribogane did not induce any ibogaine-like tremors.

Long-Lasting Ibogaine Protection against NMDA-Induced Convulsions in Mice

Ibogaine (80 mg/kg, ip) was effective in inhibiting convulsions induced by NMDA at 24 and 72 hours post administration, and [3H] MK-801 binding was significantly decreased at24 and 72 h post ibogaine, suggesting that this long lasting and complex pattern of modulation of NMDA receptors prompted by a single dose of Ibogaine may be associated to its antiaddictive properties.

In Vivo Ibogaine Blockade and In Vitro PKC Action of Cocaine a

The data obtained suggest that the PC 12 cells may be useful in studying the neurobiology of abused drugs, like cocaine in vitro, and that if anxiety is a factor in drug dependency, then the antiaddictive property of ibogaine In Vivo may be associated with modifying the CNS neurotransmission that may be involved in anxiety.



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