Effects and Action Mechanisms of Korean Pear (Pyrus pyrifolia cv. Shingo) on Alcohol Detoxification

  title={Effects and Action Mechanisms of Korean Pear (Pyrus pyrifolia cv. Shingo) on Alcohol Detoxification},
  author={Ho-Sun Lee and Toyoshi Isse and Toshihiro Kawamoto and Hyun Su Woo and An Keun Kim and Jong Yeol Park and Mihi Yang},
  journal={Phytotherapy Research},
Korean pear (Pyrus pyrifolia cv. Shingo) has been used as a traditional medicine for alleviating alcohol hangover. However, scientific evidence for its effectiveness or mechanism is not clearly established. To investigate its mechanism of alcohol detoxification, both in vitro and in vivo studies were performed with an aldehyde dehydrogenase 2 (ALDH2) alternated animal model. The pear extract (10 mL/kg bw) was administered to Aldh2 normal (C57BL/6) and deficient (Aldh2 −/−) male mice. After 30… 
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