Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer

@article{Wang2016EffectorTC,
  title={Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer},
  author={Weimin Wang and Ilona Kryczek and Lubom{\'i}r Dost{\'a}l and Heng Lin and Lijun Tan and Lili Zhao and Fujia Lu and Shuang Wei and Tomasz Maj and Dongjun Peng and Gong He and Linda Vatan and Wojciech Szeliga and Rork Kuick and Jan Kotarski and Rafał Tarkowski and Yali Dou and Ramandeep Rattan and Adnan R. Munkarah and J. Rebecca Liu and Weiping Zou},
  journal={Cell},
  year={2016},
  volume={165},
  pages={1092-1105}
}
Effector T cells and fibroblasts are major components in the tumor microenvironment. The means through which these cellular interactions affect chemoresistance is unclear. Here, we show that fibroblasts diminish nuclear accumulation of platinum in ovarian cancer cells, resulting in resistance to platinum-based chemotherapy. We demonstrate that glutathione and cysteine released by fibroblasts contribute to this resistance. CD8(+) T cells abolish the resistance by altering glutathione and cystine… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 53 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 45 extracted citations

Revisiting ovarian cancer microenvironment: a friend or a foe?

Protein & Cell • 2017
View 4 Excerpts
Highly Influenced

Glutathione in Ovarian Cancer: A Double-Edged Sword

International journal of molecular sciences • 2018
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 34 references

Cellular processing of platinum anticancer drugs

Nature Reviews Drug Discovery • 2005
View 4 Excerpts
Highly Influenced

Epigenetic silencing of TH1type chemokines shapes tumour immunity and immunotherapy

D. Peng, I. Kryczek, +7 authors W Szeliga
Nature 527, • 2015
View 9 Excerpts
Highly Influenced

Functional relevance of the histone gammaH2Ax in the response to DNA damaging agents.

Proceedings of the National Academy of Sciences of the United States of America • 2011
View 2 Excerpts
Highly Influenced

Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer.

Proceedings of the National Academy of Sciences of the United States of America • 2005
View 4 Excerpts
Highly Influenced

Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer.

The New England journal of medicine • 2003
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…