Effector Memory T cells Are Associated With Atherosclerosis in Humans and Animal Models

  title={Effector Memory T cells Are Associated With Atherosclerosis in Humans and Animal Models},
  author={Enrico Ammirati and Domenico Cianflone and Viviana Vecchio and Michela Banfi and Anna Chiara Vermi and Monica De Metrio and Liliana Grigore and Fabio Pellegatta and Angela Pirillo and Katia Garlaschelli and Angelo A. Manfredi and Alberico L. Catapano and Attilio Maseri and Alessio G. Palini and Giuseppe D. Norata},
  booktitle={Journal of the American Heart Association},
BACKGROUND#ENTITYSTARTX02014;: Adaptive T-cell response is promoted during atherogenesis and results in the differentiation of naïve CD4(+)T cells to effector and/or memory cells of specialized T-cell subsets. Aim of this work was to investigate the relationship between circulating CD4(+)T-cell subsets and atherosclerosis. METHODS AND RESULTS#ENTITYSTARTX02014;: We analyzed 57 subsets of circulating CD4(+)T cells by 10-parameter/8-color polychromatic flow cytometry (markers: CD3/CD4/CD45RO… CONTINUE READING
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